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Peptide record

TPDB22420

Antibacterial Toxicity modified_plain modified
13 amino acids
Basic Information
3D PDB MODEL
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TPDB22420
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 13-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
KWXRVYRGIYRRR
Physicochemical Analysis
C78H125N29O15
ANDCEQHLMFPST
R
1709.04
12.24
6
0
5
+6
1.08
-1.662
52.31
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8480
496.19
2
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
13
C78H125N29O15
1709.04
12.24
+6
1.08
-1.662
Evidence Records 5 records
Evidence 1 Activity

Activity

<1% Hemolysis
Toxicity
130 µM
Hemolytic Cytotoxic
<1% Hemolysis | 130 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Modified Cysteine-Deleted Tachyplesin (CDT) Analogs as Linear Antimicrobial Peptides: Influence of Chain Length, Positive Charge, and Hydrophobicity on Antimicrobial and Hemolytic Activity | Int J Pept Res Ther | 2014
Evidence 2 Activity

Activity

2.95% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
2.95% Hemolysis | 500 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Modified Cysteine-Deleted Tachyplesin (CDT) Analogs as Linear Antimicrobial Peptides: Influence of Chain Length, Positive Charge, and Hydrophobicity on Antimicrobial and Hemolytic Activity | Int J Pept Res Ther | 2014
Evidence 3 Activity

Activity

<1% Hemolysis
Toxicity
540 µM
Hemolytic Cytotoxic
<1% Hemolysis | 540 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Modified Cysteine-Deleted Tachyplesin (CDT) Analogs as Linear Antimicrobial Peptides: Influence of Chain Length, Positive Charge, and Hydrophobicity on Antimicrobial and Hemolytic Activity | Int J Pept Res Ther | 2014
Evidence 4 Activity

Activity

<1% Hemolysis
Toxicity
530 µM
Hemolytic Cytotoxic
<1% Hemolysis | 530 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Modified Cysteine-Deleted Tachyplesin (CDT) Analogs as Linear Antimicrobial Peptides: Influence of Chain Length, Positive Charge, and Hydrophobicity on Antimicrobial and Hemolytic Activity | Int J Pept Res Ther | 2014
Evidence 5 Activity

Activity

<1% Hemolysis
Toxicity
260 µM
Hemolytic Cytotoxic
<1% Hemolysis | 260 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Modified Cysteine-Deleted Tachyplesin (CDT) Analogs as Linear Antimicrobial Peptides: Influence of Chain Length, Positive Charge, and Hydrophobicity on Antimicrobial and Hemolytic Activity | Int J Pept Res Ther | 2014