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Peptide record

TPDB22407

Antibacterial Anticancer Hemolysis Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB22407
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
KVNHAACAAHCLLKRKRGGYCNKRRICVCRN
Physicochemical Analysis
C146H253N57O36S5
DEQMFPSTW
RC
3543.28
10.62
11
0
10
+9
7.10
-0.545
69.35
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1740
49.11
9
Residue Composition
number
4
A
5
R
3
N
0
D
5
C
0
E
0
Q
2
G
2
H
1
I
2
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 4 R: 5 N: 3 D: 0 C: 5 E: 0 Q: 0 G: 2 H: 2 I: 1 L: 2 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
31
C146H253N57O36S5
3543.28
10.62
+9
7.10
-0.545
Evidence Records 8 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Mouse mammary epithelial cells HC-11

Target

Mouse mammary epithelial cells HC-11

Source & Reference

NA
DBAASP
Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin. | Microorganisms | 2021
Evidence 2 Activity

Activity

20% Killing
Toxicity
400 µg/mL
Cytotoxic
20% Killing | 400 | µg/mL | target cell: Mouse mammary epithelial cells HC-11

Target

Mouse mammary epithelial cells HC-11

Source & Reference

NA
DBAASP
Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin. | Microorganisms | 2021
Evidence 3 Activity

Activity

7.28±0.1% Hemolysis
Toxicity
2.35 µM
Hemolytic Cytotoxic
7.28±0.1% Hemolysis | 2.35 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin. | Microorganisms | 2021
Evidence 4 Activity

Activity

10.0± 0.7% Hemolysis
Toxicity
4.7 µM
Hemolytic Cytotoxic
10.0± 0.7% Hemolysis | 4.7 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin. | Microorganisms | 2021
Evidence 5 Activity

Activity

12.7±0.9% Hemolysis
Toxicity
18.75 µM
Hemolytic Cytotoxic
12.7±0.9% Hemolysis | 18.75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin. | Microorganisms | 2021
Evidence 6 Activity

Activity

16.0±3.4% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
16.0±3.4% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin. | Microorganisms | 2021
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Microorganisms. 2021 Jan 22 9(2):222.
Evidence 8 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis