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Peptide record

TPDB22404

Antibacterial Anticancer Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB22404
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
KVMREVLGYERNSYK
Physicochemical Analysis
C82H134N24O24S1
ADCQHIFPTW
REKYV
1872.17
9.97
4
2
6
+2
5.67
-1.133
64.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
2980
159.17
4
Residue Composition
number
0
A
2
R
1
N
0
D
0
C
2
E
0
Q
1
G
0
H
0
I
1
L
2
K
1
M
0
F
0
P
1
S
0
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 2 M: 1 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 2 V: 2
Chemical Descriptors
15
C82H134N24O24S1
1872.17
9.97
+2
5.67
-1.133
Evidence Records 2 records
Evidence 1 Activity

Activity

14% Killing
Toxicity
128 µM
Cytotoxic
14% Killing | 128 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B. | ACS Infect Dis | 2016
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HEK-293: 14% Killing>128 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Libardo MD, Gorbatyuk VY, Angeles-Boza AM.