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Peptide record

TPDB22389

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB22389
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 CAFPdb dbAMP dbAMP 3.0
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KTCENLADTYKGPCFTTGSCDDHCKNKEHLRSGRCRDDFRCWCTKNC
Physicochemical Analysis
C222H346N72O73S8
QIMV
C
5448.11
7.85
11
7
7
+2
14.74
-1.149
18.72
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
7490
137.48
19
Residue Composition
number
1
A
4
R
3
N
5
D
8
C
2
E
0
Q
3
G
2
H
0
I
2
L
5
K
0
M
2
F
1
P
2
S
5
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 3 D: 5 C: 8 E: 2 Q: 0 G: 3 H: 2 I: 0 L: 2 K: 5 M: 0 F: 2 P: 1 S: 2 T: 5 W: 1 Y: 1 V: 0
Chemical Descriptors
47
C222H346N72O73S8
5448.11
7.85
+2
14.74
-1.149
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
7 µM
Cytotoxic
50% Cell death | 7 | µM | target cell: Normal breast cells MCF-10a

Target

Normal breast cells MCF-10a

Source & Reference

NA
DBAASP
Challenging metastatic breast cancer with the natural defensin PvD1. | Nanoscale | 2017
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MCF-10a: 50% Cell death=7 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Nanoscale. 2017 Nov 9 9(43):16887-16899.