Back to search

Peptide record

TPDB22361

Antibacterial Toxicity standard
7 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB22361
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 7-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KRWRWRW
Physicochemical Analysis
C57H80N20O8
ANDCEQGHILMFPSTYV
RW
1173.39
12.71
4
0
3
+4
-2.13
-2.871
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
1406.18
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
7
C57H80N20O8
1173.39
12.71
+4
-2.13
-2.871
Evidence Records 2 records
Evidence 1 Activity

Activity

<10% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the activity of a short arg-trp antimicrobial Peptide by lipidation of a C- or N-terminal lysine side-chain. | ACS Med Chem Lett | 2012
Evidence 2 Activity

Activity

IC50
Toxicity
32.5 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis=114 µM | Cytotoxicity: Human fibroblasts: IC50=32.5 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Comb Sci. 2013 Nov 11 15(11):585-92.