Back to search

Peptide record

TPDB22359

Antibacterial Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB22359
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 24-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KRVNWRKVGRNTALGASYVLSFLG
Physicochemical Analysis
C122H198N38O31
DCEQHIMP
RGLV
2693.15
12.14
5
0
11
+5
-0.05
-0.150
93.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6990
259.55
6
Residue Composition
number
2
A
3
R
2
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
3
L
2
K
0
M
1
F
0
P
2
S
1
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 2 R: 3 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 3 K: 2 M: 0 F: 1 P: 0 S: 2 T: 1 W: 1 Y: 1 V: 3
Chemical Descriptors
24
C122H198N38O31
2693.15
12.14
+5
-0.05
-0.150
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against E-faecium (MIC >64 uM), S. aureus (MIC 4 uM), K. pneumoniae (MIC 1 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 4 uM), E. cloac
Evidence 2 Activity

Activity

MIC
Antibacterial
1 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

Active against E-faecium (MIC >64 uM), S. aureus (MIC 4 uM), K. pneumoniae (MIC 1 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 4 uM), E. cloacae (MIC 0.5 uM), E. coli (
Evidence 3 Activity

Activity

MIC
Antibacterial
0.25 µM

Target

A. baumannii

Source & Reference

NA

Other

Active against E-faecium (MIC >64 uM), S. aureus (MIC 4 uM), K. pneumoniae (MIC 1 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 4 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 2 uM), S. Typhimurium (M
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

(MIC >64 uM), S. aureus (MIC 4 uM), K. pneumoniae (MIC 1 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 4 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 2 uM), S. Typhimurium (MIC 2 uM), and P-vulgaris (
Evidence 5 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

Enterobacter cloacae

Source & Reference

NA

Other

IC 4 uM), K. pneumoniae (MIC 1 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 4 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 2 uM), S. Typhimurium (MIC 2 uM), and P-vulgaris (MIC >64 uM). Also inhibit
Evidence 6 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli

Source & Reference

NA

Other

MIC 1 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 4 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 2 uM), S. Typhimurium (MIC 2 uM), and P-vulgaris (MIC >64 uM). Also inhibit biofilm formation.
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. Typhimurium

Source & Reference

NA

Other

nii (MIC 0.25 uM), P. aeruginosa (MIC 4 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 2 uM), S. Typhimurium (MIC 2 uM), and P-vulgaris (MIC >64 uM). Also inhibit biofilm formation.
Evidence 8 Activity

Activity

7% Cytotoxicity
Toxicity
10 µM
Cytotoxic
7% Cytotoxicity | 10 | µM | target cell: Human bronchial epithelial cells 16HBE14o-

Target

Human bronchial epithelial cells 16HBE14o-

Source & Reference

NA
DBAASP
Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens. | Antibiotics (Basel) | 2022
Evidence 9 Activity

Activity

1% Cytotoxicity
Toxicity
10 µM
Cytotoxic
1% Cytotoxicity | 10 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens. | Antibiotics (Basel) | 2022