Back to search

Peptide record

TPDB22358

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB22358
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KRVNWRKVGLGASYVMSWLG
Physicochemical Analysis
C106H167N31O25S1
DCEQHIFPT
GV
2307.74
11.51
4
0
10
+4
-1.64
-0.115
87.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
12490
541.22
4
Residue Composition
number
1
A
2
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
2
L
2
K
1
M
0
F
0
P
2
S
0
T
2
W
1
Y
3
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 2 M: 1 F: 0 P: 0 S: 2 T: 0 W: 2 Y: 1 V: 3
Chemical Descriptors
20
C106H167N31O25S1
2307.74
11.51
+4
-1.64
-0.115
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>64 µM

Target

E. faecium

Source & Reference

NA

Other

Active against E. faecium (MIC>64 uM), S. aureus (MIC 16 uM), K. pneumoniae (MIC 4 uM), A. baumannii (MIC 1 uM), P. aeruginosa
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against E. faecium (MIC>64 uM), S. aureus (MIC 16 uM), K. pneumoniae (MIC 4 uM), A. baumannii (MIC 1 uM), P. aeruginosa (MIC 8 uM), E. cloacae
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

Active against E. faecium (MIC>64 uM), S. aureus (MIC 16 uM), K. pneumoniae (MIC 4 uM), A. baumannii (MIC 1 uM), P. aeruginosa (MIC 8 uM), E. cloacae (MIC 2 uM), E. coli (MIC 4
Evidence 4 Activity

Activity

MIC
Antibacterial
1 µM

Target

A. baumannii

Source & Reference

NA

Other

Active against E. faecium (MIC>64 uM), S. aureus (MIC 16 uM), K. pneumoniae (MIC 4 uM), A. baumannii (MIC 1 uM), P. aeruginosa (MIC 8 uM), E. cloacae (MIC 2 uM), E. coli (MIC 4 uM), S. Typhimurium (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

um (MIC>64 uM), S. aureus (MIC 16 uM), K. pneumoniae (MIC 4 uM), A. baumannii (MIC 1 uM), P. aeruginosa (MIC 8 uM), E. cloacae (MIC 2 uM), E. coli (MIC 4 uM), S. Typhimurium (MIC 4 uM), and P-vulgaris (MI
Evidence 6 Activity

Activity

MIC
Antibacterial
2 µM

Target

Enterobacter cloacae

Source & Reference

NA

Other

(MIC 16 uM), K. pneumoniae (MIC 4 uM), A. baumannii (MIC 1 uM), P. aeruginosa (MIC 8 uM), E. cloacae (MIC 2 uM), E. coli (MIC 4 uM), S. Typhimurium (MIC 4 uM), and P-vulgaris (MIC >64 uM). Also inhibit
Evidence 7 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

NA

Other

iae (MIC 4 uM), A. baumannii (MIC 1 uM), P. aeruginosa (MIC 8 uM), E. cloacae (MIC 2 uM), E. coli (MIC 4 uM), S. Typhimurium (MIC 4 uM), and P-vulgaris (MIC >64 uM). Also inhibit biofilm formation.
Evidence 8 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. Typhimurium

Source & Reference

NA

Other

aumannii (MIC 1 uM), P. aeruginosa (MIC 8 uM), E. cloacae (MIC 2 uM), E. coli (MIC 4 uM), S. Typhimurium (MIC 4 uM), and P-vulgaris (MIC >64 uM). Also inhibit biofilm formation.
Evidence 9 Activity

Activity

3% Cytotoxicity
Toxicity
10 µM
Cytotoxic
3% Cytotoxicity | 10 | µM | target cell: Human bronchial epithelial cells 16HBE14o-

Target

Human bronchial epithelial cells 16HBE14o-

Source & Reference

NA
DBAASP
Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens. | Antibiotics (Basel) | 2022
Evidence 10 Activity

Activity

0% Cytotoxicity
Toxicity
10 µM
Cytotoxic
0% Cytotoxicity | 10 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens. | Antibiotics (Basel) | 2022