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Peptide record

TPDB22357

Antibacterial Toxicity standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB22357

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

KRVNWAKVGRTALKLLPYIFG

FASTA

>TPDB22357|Antibacterial;Toxicity|length=21
KRVNWAKVGRTALKLLPYIFG

Formula C116H188N32O25

Absent Amino Acids DCEQHMS

Common Amino Acids LK

Mass 2430.97

PI 11.59

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +5

Boman Index -0.49

Hydrophobicity 0.057

Aliphatic Index 111.43

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 287.54

Polar Residues 3

number

Amino Acid Distribution

A: 2 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 3 K: 3 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 1 V: 2

Length

Formula

C116H188N32O25

Mass

2430.97

11.59

Net Charge

Boman Index

-0.49

Hydrophobicity

0.057

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against E-faecium (MIC >64 uM), S. aureus (MIC 0.5 uM), K. pneumoniae (MIC 0.5 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 1 uM), E. clo

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

Active against E-faecium (MIC >64 uM), S. aureus (MIC 0.5 uM), K. pneumoniae (MIC 0.5 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.25 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source NA

Other

Evidence Text

ctive against E-faecium (MIC >64 uM), S. aureus (MIC 0.5 uM), K. pneumoniae (MIC 0.5 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 1 uM), S. Typhimurium (M

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

>64 uM), S. aureus (MIC 0.5 uM), K. pneumoniae (MIC 0.5 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 1 uM), S. Typhimurium (MIC 1 uM), and P. vulgaris

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism Enterobacter cloacae

Source & Reference

Database Source NA

Other

Evidence Text

.5 uM), K. pneumoniae (MIC 0.5 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 1 uM), S. Typhimurium (MIC 1 uM), and P. vulgaris (MIC 4 uM). Also inhibit

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

C 0.5 uM), A. baumannii (MIC 0.25 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 1 uM), S. Typhimurium (MIC 1 uM), and P. vulgaris (MIC 4 uM). Also inhibit biofilm formation.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism S. Typhimurium

Source & Reference

Database Source NA

Other

Evidence Text

nii (MIC 0.25 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 1 uM), S. Typhimurium (MIC 1 uM), and P. vulgaris (MIC 4 uM). Also inhibit biofilm formation.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism P. vulgaris

Source & Reference

Database Source NA

Other

Evidence Text

a (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 1 uM), S. Typhimurium (MIC 1 uM), and P. vulgaris (MIC 4 uM). Also inhibit biofilm formation.

Evidence 9 Activity

Activity

Activity Endpoint 48% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Cytotoxic

Toxicity Raw

48% Cytotoxicity | 10 | µM | target cell: Human bronchial epithelial cells 16HBE14o-

Target

Target Cell Human bronchial epithelial cells 16HBE14o-

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens. | Antibiotics (Basel) | 2022

Evidence 10 Activity

Activity

Activity Endpoint 50% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Cytotoxic

Toxicity Raw

50% Cytotoxicity | 10 | µM | target cell: Human PBMC

Target

Target Cell Human PBMC

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens. | Antibiotics (Basel) | 2022