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Peptide record

TPDB22297

Antibacterial Anticancer Antifungal Toxicity modified_plain modified
14 amino acids
Basic Information
3D PDB MODEL
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TPDB22297
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 14-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
KRLXKKLLKYLRKX
Physicochemical Analysis
C75H139N23O14
ANDCEQGHIMFPSTWV
K
1587.07
11.70
7
0
5
+7
3.39
-1.043
111.43
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
93.88
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
14
C75H139N23O14
1587.07
11.70
+7
3.39
-1.043
Evidence Records 3 records
Evidence 1 Activity

Activity

6.13±0.41% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
6.13±0.41% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
D- and Unnatural Amino Acid Substituted Antimicrobial Peptides With Improved Proteolytic Resistance and Their Proteolytic Degradation Characteristics. | Front Microbiol | 2020
Evidence 2 Activity

Activity

18.23±2.76% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
18.23±2.76% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
D- and Unnatural Amino Acid Substituted Antimicrobial Peptides With Improved Proteolytic Resistance and Their Proteolytic Degradation Characteristics. | Front Microbiol | 2020
Evidence 3 Activity

Activity

30.1±2.61% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
30.1±2.61% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
D- and Unnatural Amino Acid Substituted Antimicrobial Peptides With Improved Proteolytic Resistance and Their Proteolytic Degradation Characteristics. | Front Microbiol | 2020