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Peptide record

TPDB22272

Antibacterial Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB22272
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
KRIWQRIKDFLR
Physicochemical Analysis
C77H127N25O16
ANCEGHMPSTYV
R
1659.01
12.13
5
1
5
+4
2.06
-1.133
97.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
331.52
1
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
2
I
1
L
2
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 1 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C77H127N25O16
1659.01
12.13
+4
2.06
-1.133
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>340 µM
Hemolytic Cytotoxic
50% Hemolysis | >340 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short and Robust Anti-Infective Lipopeptides Engineered Based on the Minimal Antimicrobial Peptide KR12 of Human LL-37. | ACS Infect Dis | 2021
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
<25 µM
Hemolytic Cytotoxic
50% Hemolysis | <25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short and Robust Anti-Infective Lipopeptides Engineered Based on the Minimal Antimicrobial Peptide KR12 of Human LL-37. | ACS Infect Dis | 2021
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
50% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short and Robust Anti-Infective Lipopeptides Engineered Based on the Minimal Antimicrobial Peptide KR12 of Human LL-37. | ACS Infect Dis | 2021
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis