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Peptide record

TPDB22252

Antibacterial Antiparasitic Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB22252
Antibacterial Antiparasitic Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 34-aa standard natural multi-activity (Antibacterial, Antiparasitic, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KRFKKFFKKLKNSVKKRVKFFFRKPRVIGVTFPF
Physicochemical Analysis
C211H335N57O38
ADCEQHMWY
K
4278.34
12.90
14
0
14
+14
5.11
-0.532
57.06
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
4
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
10
K
0
M
8
F
2
P
1
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 10 M: 0 F: 8 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
34
C211H335N57O38
4278.34
12.90
+14
5.11
-0.532
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
2.14±0.2 µM
Cytotoxic
50% Cytotoxicity | 2.14±0.2 | µM | target cell: Murine macrophage cells J774

Target

Murine macrophage cells J774

Source & Reference

NA
DBAASP
Mechanistic Insights into the Leishmanicidal and Bactericidal Activities of Batroxicidin, a Cathelicidin-Related Peptide from a South American Viper ( Bothrops atrox). | J Nat Prod | 2021
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
29.4±13.38 µM
Cytotoxic
50% Cytotoxicity | 29.4±13.38 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Mechanistic Insights into the Leishmanicidal and Bactericidal Activities of Batroxicidin, a Cathelicidin-Related Peptide from a South American Viper ( Bothrops atrox). | J Nat Prod | 2021