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Peptide record

TPDB22249

Antibacterial standard
60 amino acids
Basic Information
3D PDB MODEL
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TPDB22249
Antibacterial
Anti-infective peptides
Peptipedia
standard
No
A 60-aa standard natural antibacterial peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KQMVDCSHYKKLPPGQQRFCHHMYDPICGSDGKTYKNDCFFCSKVKKTDGTLKFVHFGKC
Physicochemical Analysis
C308H469N85O84S8
AEW
K
6963.11
9.10
15
5
16
+6
13.48
-0.758
34.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
4845
69.58
19
Residue Composition
number
0
A
1
R
1
N
5
D
6
C
0
E
3
Q
5
G
4
H
1
I
2
L
10
K
2
M
5
F
3
P
3
S
3
T
0
W
3
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 5 C: 6 E: 0 Q: 3 G: 5 H: 4 I: 1 L: 2 K: 10 M: 2 F: 5 P: 3 S: 3 T: 3 W: 0 Y: 3 V: 3
Chemical Descriptors
60
C308H469N85O84S8
6963.11
9.10
+6
13.48
-0.758
Evidence Records 1 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against E. coli, but not P.aeruginosa NCTC 11440 and ATCC 10145, S.aureus ATCC 6538, S.pyogenes ATCC 12344 or the yeast strain C.albicans ATCC 24433 (data not shown). It is also a pH-dependent protease inhibitor (higher activity at lower pH). It is possible this peptide targets E. coli periplasmic or/and membrane proteases. Bacterial chaperon SKP is a major SPINK9-interacting protein partner. Reg. 11/2021