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Peptide record

TPDB22232

Lysine-proline-valine (KPV) Antibacterial Antifungal Hemolysis Toxicity Selfassembly standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB22232
Lysine-proline-valine (KPV)
Antibacterial Antifungal Hemolysis Toxicity Selfassembly
Anti-infective peptides Toxicity and safety peptides Self-assembling and biomaterial peptides
Peptipedia CAFPdb dbAMP PD_Hemolysis SAPdb
standard
No
A 3-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
KPV
Physicochemical Analysis
C16H30N4O4
ARNDCEQGHILMFSTWY
KPV
342.44
10.10
1
0
1
+1
1.51
-0.433
96.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
3
C16H30N4O4
342.44
10.10
+1
1.51
-0.433
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

28143741
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
pH: 5.5 temperature: –20°C solvent: MES buffer
Selfassembly; Nanostructure=Nanoparticles; Trigger=pH: 5.5; temperature: –20°C; solvent: MES buffer
flow cytometry (FCM)
Selfassembly
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
62.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 62.5 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Lipidated Short Analogue of α-Melanocyte Stimulating Hormone Exerts Bactericidal Activity against the Stationary Phase of Methicillin-Resistant Staphylococcus aureus and Inhibits Biofilm Formation. | ACS Omega | 2020
Evidence 2 Activity

Activity

14.5% Killing
Toxicity
50 µM
Cytotoxic
14.5% Killing | 50 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Lipidated Short Analogue of α-Melanocyte Stimulating Hormone Exerts Bactericidal Activity against the Stationary Phase of Methicillin-Resistant Staphylococcus aureus and Inhibits Biofilm Formation. | ACS Omega | 2020
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles Trigger=pH: 5.5 temperature: –20°C solvent: MES buffer
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 5.5 temperature: –20°C solvent: MES buffer
flow cytometry (FCM)
28143741
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1910 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Additional Detail Fields 5 fields
pH: 5.5 temperature: –20°C solvent: MES buffer
None specified
SAPdb ID 1910 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
28143741
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly