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Peptide record

TPDB22164

Antibacterial Anticancer Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB22164
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
KLYKKFRHILKKVWHYVGKI
Physicochemical Analysis
C128H202N34O23
ANDCEQMPST
K
2585.23
10.90
9
0
10
+7
2.22
-0.520
107.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8480
328.02
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
2
H
2
I
2
L
6
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 2 L: 2 K: 6 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 2
Chemical Descriptors
20
C128H202N34O23
2585.23
10.90
+7
2.22
-0.520
Evidence Records 5 records
Evidence 1 Activity

Activity

HC50
Hemolysis
29
Human erythrocytes: HC50=29 ± 3 µM

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Sci Rep. 2019 Aug 2 9(1):11282.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

EC50
Toxicity
10±3 µM
Cytotoxic
EC50 | 10±3 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
29±3 µM
Hemolytic Cytotoxic
50% Hemolysis | 29±3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 4 Activity

Activity

HC50
Toxicity
29
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=29 ± 3 µM | Cytotoxicity: HDMEC: EC50=10 ± 3 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.
Evidence 5 Hemolysis

Activity

29
HC50
Human erythrocytes: HC50=29 ± 3 µM
Hemolysis

Target

Human erythrocytes

Source & Reference

PD_Hemolysis
Sci Rep. 2019 Aug 2 9(1):11282.
DRAMP4
PD_Hemolysis