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Peptide record

TPDB22139

Antibacterial Anticancer Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB22139
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
KLLPSVVGLFKKKKQ
Physicochemical Analysis
C82H145N21O18
ARNDCEHIMTWY
K
1713.18
11.12
5
0
6
+5
3.45
-0.213
116.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
3
L
5
K
0
M
1
F
1
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 3 K: 5 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
15
C82H145N21O18
1713.18
11.12
+5
3.45
-0.213
Evidence Records 4 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
0% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Highly selective performance of rationally designed antimicrobial peptides based on ponericin-W1. | Biomater Sci | 2022
Evidence 2 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Anticancer effect of rationally designed α-helical amphiphilic peptides | Colloids Surf B Biointerfaces | 2022
Evidence 3 Activity

Activity

0% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
0% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anticancer effect of rationally designed α-helical amphiphilic peptides | Colloids Surf B Biointerfaces | 2022
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Colloids Surf B Biointerfaces. 2022 Dec 220:112841.