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Peptide record

TPDB22120

Antibacterial Anticancer Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB22120
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
KLLKKVVKLFKKLLK
Physicochemical Analysis
C91H168N22O16
ARNDCEQGHIMPSTWY
K
1826.47
11.29
7
0
8
+7
3.14
0.193
168.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
5
L
7
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 7 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
15
C91H168N22O16
1826.47
11.29
+7
3.14
0.193
Evidence Records 5 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
31 µM
Hemolytic Cytotoxic
<5% Hemolysis | 31 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Highly selective performance of rationally designed antimicrobial peptides based on ponericin-W1. | Biomater Sci | 2022
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
62 µM
Hemolytic Cytotoxic
10% Hemolysis | 62 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Highly selective performance of rationally designed antimicrobial peptides based on ponericin-W1. | Biomater Sci | 2022
Evidence 3 Activity

Activity

IC50
Toxicity
7.1 µM
Cytotoxic
IC50 | 7.1 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Anticancer effect of rationally designed α-helical amphiphilic peptides | Colloids Surf B Biointerfaces | 2022
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anticancer effect of rationally designed α-helical amphiphilic peptides | Colloids Surf B Biointerfaces | 2022
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Colloids Surf B Biointerfaces. 2022 Dec 220:112843.