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Peptide record

TPDB22118

Antibacterial Anticancer Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB22118
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
KLLKKLLKLLKKLLK
Physicochemical Analysis
C90H174N22O16
ARNDCEQGHIMFPSTWYV
L
1820.51
11.29
7
0
8
+7
2.45
0.207
208.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
8
L
7
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 7 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C90H174N22O16
1820.51
11.29
+7
2.45
0.207
Evidence Records 4 records
Evidence 1 Activity

Activity

65% Hemolysis
Toxicity
25-200 µM
Hemolytic Cytotoxic
65% Hemolysis | 25-200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Highly selective performance of rationally designed antimicrobial peptides based on ponericin-W1. | Biomater Sci | 2022
Evidence 2 Activity

Activity

IC50
Toxicity
5.7 µM
Cytotoxic
IC50 | 5.7 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Anticancer effect of rationally designed α-helical amphiphilic peptides | Colloids Surf B Biointerfaces | 2022
Evidence 3 Activity

Activity

62% Hemolysis
Toxicity
25-200 µM
Hemolytic Cytotoxic
62% Hemolysis | 25-200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anticancer effect of rationally designed α-helical amphiphilic peptides | Colloids Surf B Biointerfaces | 2022
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Colloids Surf B Biointerfaces. 2022 Dec 220:112844.