TPDB

3D PDB MODEL

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TPDB ID TPDB22109

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

KLFLTLWKLKR

FASTA

>TPDB22109|Antibacterial;Toxicity|length=11
KLFLTLWKLKR

Formula C72H120N18O13

Absent Amino Acids ANDCEQGHIMPSYV

Common Amino Acids L

Mass 1445.86

PI 11.73

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +4

Boman Index -1.30

Hydrophobicity 0.018

Aliphatic Index 141.82

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 380.40

Polar Residues 1

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

4

L

3

K

0

M

1

F

0

P

0

S

1

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0

Length

11

Formula

C72H120N18O13

Mass

1445.86

PI

11.73

Net Charge

+4

Boman Index

-1.30

Hydrophobicity

0.018

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S. enteritidis (MIC 64 ug/ml), and S.aureus ATCC 29213 (MIC 128 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S. enteritidis (MIC 64 ug/ml), and S.aureus ATCC 29213 (MIC 128 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S. enteritidis (MIC 64 ug/ml), and S.aureus ATCC 29213 (MIC 128 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022