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Peptide record

TPDB22100

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB22100
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KLIHRLKTVFKKVWHFLGHL
Physicochemical Analysis
C123H194N34O22
ANDCEQMPSY
LK
2501.11
11.80
8
0
10
+5
1.28
0.100
126.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
219.90
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
3
H
1
I
4
L
4
K
0
M
2
F
0
P
0
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 3 I: 1 L: 4 K: 4 M: 0 F: 2 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
20
C123H194N34O22
2501.11
11.80
+5
1.28
0.100
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
22±3 µM
Cytotoxic
EC50 | 22±3 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
41±3 µM
Hemolytic Cytotoxic
50% Hemolysis | 41±3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

HC50
Toxicity
41
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=41 ± 3 µM | Cytotoxicity: HDMEC: EC50=22 ± 3 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.