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Peptide record

TPDB22060

Antibacterial Antifungal Antiparasitic Toxicity modified_plain modified
26 amino acids
Basic Information
3D PDB MODEL
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TPDB22060
Antibacterial Antifungal Antiparasitic Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP dbAMP 3.0
modified_plain
Yes
A 26-aa modified multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Modified, details unspecified
Sequence
KKALLXHALHXLALLAXHLAHXLKKA
Physicochemical Analysis
C114H196N34O23
RNDCEQGIMFPSTWYV
L
2411.02
11.00
8
0
14
+4
2.30
0.492
143.08
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
4
H
0
I
8
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 8 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
26
C114H196N34O23
2411.02
11.00
+4
2.30
0.492
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
179.2 µM
Hemolytic Cytotoxic
50% Hemolysis | 179.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural determinants of antimicrobial and antiplasmodial activity and selectivity in histidine-rich amphipathic cationic peptides. | J Biol Chem | 2009
Evidence 2 Activity

Activity

50% Cell death
Toxicity
38.0±2.9 µM
Cytotoxic
50% Cell death | 38.0±2.9 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Structural determinants of antimicrobial and antiplasmodial activity and selectivity in histidine-rich amphipathic cationic peptides. | J Biol Chem | 2009
Evidence 3 Activity

Activity

50% Cell death
Toxicity
26.5±2.0 µM
Cytotoxic
50% Cell death | 26.5±2.0 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
Structural determinants of antimicrobial and antiplasmodial activity and selectivity in histidine-rich amphipathic cationic peptides. | J Biol Chem | 2009