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Peptide record

TPDB22050

Antibacterial Anticancer Toxicity modified_plain modified
9 source-reported length (unverified)
Basic Information
TPDB22050
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide record curated from Peptipedia, without an available 3D structural model. Source-reported length: 9 (unverified).
Modified, details unspecified
Sequence
KKXWKKWWK

Source notation is retained verbatim; residue notation and chemical identity have not been independently validated. The displayed length is source-reported and unverified.

Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
9 source-reported length (unverified)
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
Toxicity
488±52 µM
Cytotoxic
IC50 | 488±52 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. | J Med Chem | 2016
Evidence 2 Activity

Activity

IC50
Toxicity
151±16 µM
Cytotoxic
IC50 | 151±16 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. | J Med Chem | 2016
Evidence 3 Activity

Activity

IC50
Toxicity
37.9±9.1 µM
Cytotoxic
IC50 | 37.9±9.1 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. | J Med Chem | 2016
Evidence 4 Activity

Activity

IC50
Toxicity
488
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MRC-5: IC50=488 ± 52 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Apr 14 59(7):2918-27.
Evidence 5 Activity

Activity

IC50
Toxicity
151
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MRC-5: IC50=151 ± 16 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Apr 14 59(7):2918-27.