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Peptide record

TPDB22044

Antibacterial Toxicity modified_plain modified
4 amino acids
Basic Information
3D PDB MODEL
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TPDB22044
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 4-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
KKXK
Physicochemical Analysis
C18H38N6O4
ARNDCEQGHILMFPSTWYV
K
402.54
10.84
3
0
0
+3
2.97
-2.925
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C18H38N6O4
402.54
10.84
+3
2.97
-2.925
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Sensitization of Gram-negative bacteria to rifampin and OAK combinations. | Sci Rep | 2015
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A broad-spectrum bactericidal lipopeptide with anti-biofilm properties. | Sci Rep | 2017
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
29±9 µM
Hemolytic Cytotoxic
50% Hemolysis | 29±9 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Sensitization of Gram-negative bacteria to rifampin and OAK combinations. | Sci Rep | 2015
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
15±1.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 15±1.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Impact of self-assembly properties on antibacterial activity of short acyl-lysine oligomers. | Antimicrob Agents Chemother | 2008