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Peptide record

TPDB22015

TMTP1 Antibacterial Anticancer Antifungal Toxicity Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB22015
TMTP1
Antibacterial Anticancer Antifungal Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia AntiCP 2.0 CancerPPD 2.0 iACP-DRLF TumorHoPe2.0
standard
No
A 7-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiCP 2.0, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
KLAKLAK
Physicochemical Analysis
C36H70N10O8
RNDCEQGHIMFPSTWYV
K
771.01
10.84
3
0
4
+3
1.51
-0.071
140.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C36H70N10O8
771.01
10.84
+3
1.51
-0.071
Evidence Records 3 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
<500 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | <500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo antimicrobial peptides with low mammalian cell toxicity. | J Med Chem | 1996
Evidence 2 Activity

Activity

0% Killing
Toxicity
400 µM
Cytotoxic
0% Killing | 400 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
De novo antimicrobial peptides with low mammalian cell toxicity. | J Med Chem | 1996
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Additional Detail Fields 3 fields
necrosis-inducing peptide, Fluorescein (FAM)
Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice