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Peptide record

TPDB22003

Antibacterial Anticancer Toxicity modified_plain modified
9 amino acids
Basic Information
3D PDB MODEL
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TPDB22003
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 9-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
KKWXKKWWK
Physicochemical Analysis
C63H92N16O9
ARNDCEQGHILMFPSTYV
K
1217.53
11.12
5
0
3
+5
-0.60
-2.467
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
1355.21
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
9
C63H92N16O9
1217.53
11.12
+5
-0.60
-2.467
Evidence Records 10 records
Evidence 1 Activity

Activity

IC50
Toxicity
287±52 µM
Cytotoxic
IC50 | 287±52 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. | J Med Chem | 2016
Evidence 2 Activity

Activity

IC50
Toxicity
174±22 µM
Cytotoxic
IC50 | 174±22 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. | J Med Chem | 2016
Evidence 3 Activity

Activity

IC50
Toxicity
238±69 µM
Cytotoxic
IC50 | 238±69 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. | J Med Chem | 2016
Evidence 4 Activity

Activity

IC50
Toxicity
257±20 µM
Cytotoxic
IC50 | 257±20 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. | J Med Chem | 2016
Evidence 5 Activity

Activity

IC50
Toxicity
40.0±1.7 µM
Cytotoxic
IC50 | 40.0±1.7 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. | J Med Chem | 2016
Evidence 6 Activity

Activity

IC50
Toxicity
287
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MRC-5: IC50=287 ± 52 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Apr 14 59(7):2918-27.
Evidence 7 Activity

Activity

IC50
Toxicity
174
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MRC-5: IC50=174 ± 22 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Apr 14 59(7):2918-27.
Evidence 8 Activity

Activity

IC50
Toxicity
238
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MRC-5: IC50=238 ± 69 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Apr 14 59(7):2918-27.
Evidence 9 Activity

Activity

IC50
Toxicity
257
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MRC-5: IC50=257 ± 20 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Apr 14 59(7):2918-27.
Evidence 10 Activity

Activity

IC50
Toxicity
40.0
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MRC-5: IC50=40.0 ± 1.7 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Apr 14 59(7):2918-27.