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Peptide record

TPDB21995

Antibacterial Anticancer Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB21995
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KKWWKKWWK
Physicochemical Analysis
C74H102N18O10
ARNDCEQGHILMFPSTYV
K
1403.74
11.12
5
0
4
+5
-2.45
-2.567
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
22000
1567.24
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
9
C74H102N18O10
1403.74
11.12
+5
-2.45
-2.567
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Toxicity
>357 µM
Cytotoxic
IC50 | >357 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. | J Med Chem | 2016
Evidence 2 Activity

Activity

IC50
Toxicity
357 µM
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MRC-5: IC50>357 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Apr 14 59(7):2918-27.