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Peptide record

TPDB21971

Antibacterial Antifungal Antiviral Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB21971
Antibacterial Antifungal Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from Peptipedia, CAFPdb, AI4AVP, and other sources, with an available 3D structural model.
Sequence
KKVTMTCSAS
Physicochemical Analysis
C42H78N12O15S2
RNDEQGHILFPWY
KST
1055.27
9.90
2
0
3
+2
1.95
-0.040
39.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
1
A
0
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
1
M
0
F
0
P
2
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 1 F: 0 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
10
C42H78N12O15S2
1055.27
9.90
+2
1.95
-0.040
Evidence Records 8 records
Evidence 1 Activity

Activity

20% Killing
Toxicity
100 µg/mL
Cytotoxic
20% Killing | 100 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins. | Intervirology | 2018
Evidence 2 Activity

Activity

2.42% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
2.42% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In Vitro and In Vivo Anti- Candida Activity and Structural Analysis of Killer Peptide (KP)-Derivatives. | J Fungi (Basel) | 2021
Evidence 3 Activity

Activity

6.26% Killing
Toxicity
10 µM
Cytotoxic
6.26% Killing | 10 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
In Vitro and In Vivo Anti- Candida Activity and Structural Analysis of Killer Peptide (KP)-Derivatives. | J Fungi (Basel) | 2021
Evidence 4 Activity

Activity

0% Killing
Toxicity
25 µM
Cytotoxic
0% Killing | 25 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
In Vitro and In Vivo Anti- Candida Activity and Structural Analysis of Killer Peptide (KP)-Derivatives. | J Fungi (Basel) | 2021
Evidence 5 Activity

Activity

9.05% Killing
Toxicity
50 µM
Cytotoxic
9.05% Killing | 50 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
In Vitro and In Vivo Anti- Candida Activity and Structural Analysis of Killer Peptide (KP)-Derivatives. | J Fungi (Basel) | 2021
Evidence 6 Activity

Activity

<2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
<2% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In Silico Predicted Antifungal Peptides: In Vitro and In Vivo Anti- Candida Activity. | J Fungi (Basel) | 2021
Evidence 7 Activity

Activity

0% Killing
Toxicity
200 µM
Cytotoxic
0% Killing | 200 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
In Silico Predicted Antifungal Peptides: In Vitro and In Vivo Anti- Candida Activity. | J Fungi (Basel) | 2021
Evidence 8 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.30654366]20% cytotoxicity against Vero cells at the concentration of 100µg/ mL.

Source & Reference

NA
DRAMP
Intervirology. 2018 61(4):166-173.