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Peptide record

TPDB21960

Antibacterial Antifungal Toxicity modified_plain modified
11 amino acids
Basic Information
3D PDB MODEL
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TPDB21960
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 11-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
KKLXKKILKYL
Physicochemical Analysis
C63H115N15O12
ARNDCEQGHMFPSTWV
K
1274.70
10.77
5
0
5
+5
2.02
-0.445
141.82
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
116.89
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C63H115N15O12
1274.70
10.77
+5
2.02
-0.445
Evidence Records 10 records
Evidence 1 Activity

Activity

75±4% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
75±4% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 2 Activity

Activity

95±3% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
95±3% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 3 Activity

Activity

22±4% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
22±4% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 4 Activity

Activity

40±4% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
40±4% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 5 Activity

Activity

100±2% Hemolysis
Toxicity
250-375 µM
Hemolytic Cytotoxic
100±2% Hemolysis | 250-375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 6 Activity

Activity

4% Hemolysis
Toxicity
1.25-2.5 µM
Hemolytic Cytotoxic
4% Hemolysis | 1.25-2.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 7 Activity

Activity

7% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
7% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 8 Activity

Activity

10% Hemolysis
Toxicity
10-20 µM
Hemolytic Cytotoxic
10% Hemolysis | 10-20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 9 Activity

Activity

8% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
8% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 10 Activity

Activity

5% Hemolysis
Toxicity
80-160 µM
Hemolytic Cytotoxic
5% Hemolysis | 80-160 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016