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Peptide record

TPDB21943

Antibacterial Anticancer Toxicity modified_plain modified
7 amino acids
Basic Information
3D PDB MODEL
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TPDB21943
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 7-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
KKLKXFX
Physicochemical Analysis
C33H58N8O6
ARNDCEQGHIMPSTWYV
K
662.87
10.84
3
0
2
+3
1.28
-0.729
55.71
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C33H58N8O6
662.87
10.84
+3
1.28
-0.729
Evidence Records 17 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
10% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections. | Sci Rep | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
58 µM
Hemolytic Cytotoxic
50% Hemolysis | 58 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections. | Sci Rep | 2019
Evidence 3 Activity

Activity

96% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
96% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections. | Sci Rep | 2019
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
10% Hemolysis | >150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 5 Activity

Activity

<8% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
<8% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
50% Hemolysis | >150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 7 Activity

Activity

19.7% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
19.7% Hemolysis | 150 | µM | target cell: Dog erythrocytes

Target

Dog erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 8 Activity

Activity

10% Hemolysis
Toxicity
34.2 µM
Hemolytic Cytotoxic
10% Hemolysis | 34.2 | µM | target cell: Dog erythrocytes

Target

Dog erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
50% Hemolysis | >150 | µM | target cell: Dog erythrocytes

Target

Dog erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 10 Activity

Activity

<8% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
<8% Hemolysis | 150 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 11 Activity

Activity

10% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
10% Hemolysis | >150 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
50% Hemolysis | >150 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 13 Activity

Activity

32.5% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
32.5% Hemolysis | 150 | µM | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 14 Activity

Activity

10% Hemolysis
Toxicity
45.1 µM
Hemolytic Cytotoxic
10% Hemolysis | 45.1 | µM | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 15 Activity

Activity

50% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
50% Hemolysis | >150 | µM | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 16 Activity

Activity

50% Cell death
Toxicity
654 µM
Cytotoxic
50% Cell death | 654 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides | Sci Rep | 2020
Evidence 17 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2020 Aug 6 10(1):13207.