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Peptide record

TPDB21942

Antibacterial Antifungal Toxicity modified_plain modified
10 amino acids
Basic Information
3D PDB MODEL
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TPDB21942
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 10-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
KKLKXFKKLQ
Physicochemical Analysis
C56H101N15O11
ARNDCEGHIMPSTWYV
K
1160.51
11.12
5
0
3
+5
3.28
-1.260
78.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
2
L
5
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C56H101N15O11
1160.51
11.12
+5
3.28
-1.260
Evidence Records 19 records
Evidence 1 Activity

Activity

67% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
67% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A convenient solid-phase strategy for the synthesis of antimicrobial cyclic lipopeptides. | Org Biomol Chem | 2013
Evidence 2 Activity

Activity

78% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
78% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A convenient solid-phase strategy for the synthesis of antimicrobial cyclic lipopeptides. | Org Biomol Chem | 2013
Evidence 3 Activity

Activity

15% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
15% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A convenient solid-phase strategy for the synthesis of antimicrobial cyclic lipopeptides. | Org Biomol Chem | 2013
Evidence 4 Activity

Activity

28% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
28% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A convenient solid-phase strategy for the synthesis of antimicrobial cyclic lipopeptides. | Org Biomol Chem | 2013
Evidence 5 Activity

Activity

52% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
52% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A convenient solid-phase strategy for the synthesis of antimicrobial cyclic lipopeptides. | Org Biomol Chem | 2013
Evidence 6 Activity

Activity

100% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
100% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A convenient solid-phase strategy for the synthesis of antimicrobial cyclic lipopeptides. | Org Biomol Chem | 2013
Evidence 7 Activity

Activity

62% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
62% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A convenient solid-phase strategy for the synthesis of antimicrobial cyclic lipopeptides. | Org Biomol Chem | 2013
Evidence 8 Activity

Activity

89% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
89% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A convenient solid-phase strategy for the synthesis of antimicrobial cyclic lipopeptides. | Org Biomol Chem | 2013
Evidence 9 Activity

Activity

62% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
62% Hemolysis | 150 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine. | PLoS One | 2016
Evidence 10 Activity

Activity

78% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
78% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine. | PLoS One | 2016
Evidence 11 Activity

Activity

89% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
89% Hemolysis | 150 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine. | PLoS One | 2016
Evidence 12 Activity

Activity

93% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
93% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine. | PLoS One | 2016
Evidence 13 Activity

Activity

98% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
98% Hemolysis | 150 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine. | PLoS One | 2016
Evidence 14 Activity

Activity

100% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
100% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine. | PLoS One | 2016
Evidence 15 Activity

Activity

100% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
100% Hemolysis | 150 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine. | PLoS One | 2016
Evidence 16 Activity

Activity

93% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
93% Hemolysis | 150 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine. | PLoS One | 2016
Evidence 17 Activity

Activity

96% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
96% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine. | PLoS One | 2016
Evidence 18 Activity

Activity

91% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
91% Hemolysis | 150 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine. | PLoS One | 2016
Evidence 19 Activity

Activity

97% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
97% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine. | PLoS One | 2016