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Peptide record

TPDB21934

Antibacterial Antifungal Toxicity modified_plain modified
11 amino acids
Basic Information
3D PDB MODEL
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TPDB21934
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 11-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
KKLFKKXLKYL
Physicochemical Analysis
C66H113N15O12
ARNDCEQGHIMPSTWV
K
1308.72
10.77
5
0
5
+5
1.20
-0.600
106.36
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
113.85
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
5
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C66H113N15O12
1308.72
10.77
+5
1.20
-0.600
Evidence Records 9 records
Evidence 1 Activity

Activity

19±3% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
19±3% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 2 Activity

Activity

28±2% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
28±2% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 3 Activity

Activity

1±0.1% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
1±0.1% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 4 Activity

Activity

3±0% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
3±0% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 5 Activity

Activity

100±5% Hemolysis
Toxicity
250-375 µM
Hemolytic Cytotoxic
100±5% Hemolysis | 250-375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 6 Activity

Activity

1% Hemolysis
Toxicity
1.25 µM
Hemolytic Cytotoxic
1% Hemolysis | 1.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 7 Activity

Activity

3% Hemolysis
Toxicity
2.5-5 µM
Hemolytic Cytotoxic
3% Hemolysis | 2.5-5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 8 Activity

Activity

5% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
5% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 9 Activity

Activity

7% Hemolysis
Toxicity
20-160 µM
Hemolytic Cytotoxic
7% Hemolysis | 20-160 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016