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Peptide record

TPDB21932

Antibacterial Antifungal Toxicity modified_plain modified
11 amino acids
Basic Information
3D PDB MODEL
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TPDB21932
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 11-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
KKLFKKILXYL
Physicochemical Analysis
C66H112N14O12
ARNDCEQGHMPSTWV
K
1293.70
10.64
4
0
6
+4
-0.10
0.164
141.82
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
115.17
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
4
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C66H112N14O12
1293.70
10.64
+4
-0.10
0.164
Evidence Records 11 records
Evidence 1 Activity

Activity

90±4% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
90±4% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 2 Activity

Activity

89±2% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
89±2% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 3 Activity

Activity

38±4% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
38±4% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 4 Activity

Activity

89±10% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
89±10% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 5 Activity

Activity

99±0.4% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
99±0.4% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 6 Activity

Activity

100±14% hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
100±14% hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 7 Activity

Activity

7% Hemolysis
Toxicity
2.5-5 µM
Hemolytic Cytotoxic
7% Hemolysis | 2.5-5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 8 Activity

Activity

13% Hemolysis
Toxicity
10-20 µM
Hemolytic Cytotoxic
13% Hemolysis | 10-20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 9 Activity

Activity

22% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
22% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 10 Activity

Activity

38% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
38% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 11 Activity

Activity

57% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
57% Hemolysis | 160 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016