Back to search

Peptide record

TPDB21929

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB21929
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
KKLFKKILKYLKK
Physicochemical Analysis
C84H148N20O15
ARNDCEQGHMPSTWV
K
1678.22
10.95
7
0
6
+7
2.87
-0.762
120.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
88.78
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
7
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 7 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C84H148N20O15
1678.22
10.95
+7
2.87
-0.762
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
89.6±7.2 µM
Cytotoxic
IC50 | 89.6±7.2 | µM | target cell: Human gastric epithelial cells GES-1

Target

Human gastric epithelial cells GES-1

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel peptides based on antimicrobial peptides as potential agents with anti-tumor and multidrug resistance-reversing activities | Chem Biol Drug Des | 2017
Evidence 2 Activity

Activity

<10% Hemolysis
Toxicity
240 µM
Hemolytic Cytotoxic
<10% Hemolysis | 240 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel peptides based on antimicrobial peptides as potential agents with anti-tumor and multidrug resistance-reversing activities | Chem Biol Drug Des | 2017
Evidence 3 Activity

Activity

IC50
Toxicity
89.6
Hemolytic Cytotoxic
Hemolytic_activity: Rabbit red blood cells: very low hemolytic activity even at the concentration of 160 µm(as show in fig.3) | Cytotoxicity: GES-1: IC50=89.6±7.2 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2017 Nov 90(5):972-980.