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Peptide record

TPDB21928

Antibacterial Anticancer Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB21928
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
KKLFKKILKYLK
Physicochemical Analysis
C78H136N18O14
ARNDCEQGHMPSTWV
K
1550.05
10.87
6
0
6
+6
1.88
-0.500
130.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
96.13
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
6
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 6 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C78H136N18O14
1550.05
10.87
+6
1.88
-0.500
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
52.3±4.5 µM
Cytotoxic
IC50 | 52.3±4.5 | µM | target cell: Human gastric epithelial cells GES-1

Target

Human gastric epithelial cells GES-1

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel peptides based on antimicrobial peptides as potential agents with anti-tumor and multidrug resistance-reversing activities | Chem Biol Drug Des | 2017
Evidence 2 Activity

Activity

<10% Hemolysis
Toxicity
240 µM
Hemolytic Cytotoxic
<10% Hemolysis | 240 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel peptides based on antimicrobial peptides as potential agents with anti-tumor and multidrug resistance-reversing activities | Chem Biol Drug Des | 2017
Evidence 3 Activity

Activity

IC50
Toxicity
52.3
Hemolytic Cytotoxic
Hemolytic_activity: Rabbit red blood cells: very low hemolytic activity even at the concentration of 160 µm(as show in fig.3) | Cytotoxicity: GES-1: IC50=52.3±4.5 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2017 Nov 90(5):972-980.