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Peptide record

TPDB21923

Antibacterial Anticancer Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB21923
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KKLFKKILKRL
Physicochemical Analysis
C69H127N19O12
ANDCEQGHMPSTWYV
K
1414.89
11.85
6
0
5
+6
2.64
-0.482
141.82
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
5
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C69H127N19O12
1414.89
11.85
+6
2.64
-0.482
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
81.9±7.3 µM
Cytotoxic
IC50 | 81.9±7.3 | µM | target cell: Human gastric epithelial cells GES-1

Target

Human gastric epithelial cells GES-1

Source & Reference

NA
DBAASP
Design, synthesis and biological evaluation of novel peptides as potential agents with anti-tumor and multidrug resistance-reversing activities. | Amino Acids | 2017
Evidence 2 Activity

Activity

5% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
5% Hemolysis | 160 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Design, synthesis and biological evaluation of novel peptides as potential agents with anti-tumor and multidrug resistance-reversing activities. | Amino Acids | 2017
Evidence 3 Activity

Activity

IC50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: Rabbit erythrocytes: 5% Hemolysis=160µM | Cytotoxicity: GES-1: IC50>100µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2017 Aug 49(8):1355-1364