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Peptide record

TPDB21903

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB21903
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP PD_Hemolysis
standard
No
A 4-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
KKKR
Physicochemical Analysis
C24H50N10O5
ANDCEQGHILMFPSTWYV
K
558.73
11.73
4
0
0
+4
3.78
-4.050
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C24H50N10O5
558.73
11.73
+4
3.78
-4.050
Evidence Records 7 records
Evidence 1 Activity

Activity

HC50
Hemolysis
89.7
Human erythrocytes:HC50=89.7±2.4µg/ml

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Int J Mol Sci. 2020 Sep 29 21(19):7208.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
89.7±2.4 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 89.7±2.4 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity. | Int J Mol Sci | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
7.5±0.8 µg/mL
Cytotoxic
IC50 | 7.5±0.8 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity. | Int J Mol Sci | 2020
Evidence 4 Activity

Activity

IC50
Toxicity
32.5±10.0 µg/mL
Cytotoxic
IC50 | 32.5±10.0 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Understanding the Role of Self-Assembly and Interaction with Biological Membranes of Short Cationic Lipopeptides in the Effective Design of New Antibiotics | Antibiotics (Basel) | 2022
Evidence 5 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Understanding the Role of Self-Assembly and Interaction with Biological Membranes of Short Cationic Lipopeptides in the Effective Design of New Antibiotics | Antibiotics (Basel) | 2022
Evidence 6 Activity

Activity

HC50
Toxicity
89.7
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:HC50=89.7±2.4µg/ml | Cytotoxicity: HaCat: IC50=7.5±0.8µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2020 Sep 29 21(19):7208.
Evidence 7 Hemolysis

Activity

89.7
HC50
Human erythrocytes:HC50=89.7±2.4µg/ml
Hemolysis

Target

Human erythrocytes

Source & Reference

PD_Hemolysis
Int J Mol Sci. 2020 Sep 29 21(19):7208.
DRAMP4
PD_Hemolysis