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Peptide record

TPDB21872

Antibacterial Anticancer Antifungal Cell-penetrating Peptides Hemolysis Toxicity standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB21872
Antibacterial Anticancer Antifungal Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia CancerPPD 2.0 CAFPdb CPPsite3.0 PD_Hemolysis ToxinPred 3.0
standard
No
A 4-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KKKK
Physicochemical Analysis
C24H50N8O5
ARNDCEQGHILMFPSTWYV
K
530.71
11.00
4
0
0
+4
3.96
-3.900
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C24H50N8O5
530.71
11.00
+4
3.96
-3.900
Evidence Records 7 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 16 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
105.9±8 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 105.9±8 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity. | Int J Mol Sci | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
23.5±1.3 µg/mL
Cytotoxic
IC50 | 23.5±1.3 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity. | Int J Mol Sci | 2020
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
1000 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 1000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
>4000 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >4000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 7 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis