Back to search

Peptide record

TPDB21844

Di- lysine or KK dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Antifungal Hemolysis Toxicity iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB21844
Di- lysine or KK dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Antifungal Hemolysis Toxicity iDPPIV Selfassembly
Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides Self-assembling and biomaterial peptides
Peptipedia CAFPdb dbAMP PD_Hemolysis iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
KK
Physicochemical Analysis
C12H26N4O3
ARNDCEQGHILMFPSTWYV
K
274.36
10.60
2
0
0
+2
1.98
-3.900
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C12H26N4O3
274.36
10.60
+2
1.98
-3.900
274.3588
274.1999
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

25377526
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanofiber Fibril bundles
pH: 1.9 or < 2.0 temperature: Room temperature solvent: Water + Tetraphenylporphyrin concentration: 0.1M
Selfassembly; Nanostructure=Nanofiber; Fibril bundles; Trigger=pH: 1.9 or < 2.0; temperature: Room temperature; solvent: Water + Tetraphenylporphyrin; concentration: 0.1M
Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and AFM (Atomic Force Microscopy)
Selfassembly
Evidence Records 11 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 16 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Understanding the Role of Self-Assembly and Interaction with Biological Membranes of Short Cationic Lipopeptides in the Effective Design of New Antibiotics | Antibiotics (Basel) | 2022
Evidence 3 Activity

Activity

IC50
Toxicity
0.69±0.001 µg/mL
Cytotoxic
IC50 | 0.69±0.001 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Understanding the Role of Self-Assembly and Interaction with Biological Membranes of Short Cationic Lipopeptides in the Effective Design of New Antibiotics | Antibiotics (Basel) | 2022
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
50% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Small lipopeptides possess anti-biofilm capability comparable to daptomycin and vancomycin. | RSC Adv | 2015
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
>4000 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >4000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Small lipopeptides possess anti-biofilm capability comparable to daptomycin and vancomycin. | RSC Adv | 2015
Evidence 7 Activity

Activity

10% Hemolysis
Toxicity
4000 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 4000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 8 Activity

Activity

10% Hemolysis
Toxicity
>4000 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >4000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 9 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C12H26N4O3/c13-7-3-1-5-9(15)11(17)16-10(12(18)19)6-2-4-8-14/h9-10H,1-8,13-15H2,(H,16,17)(H,18,19)/t9-,10-/m0/s1 InChIKey=NVGBPTNZLWRQSY-UWVGGRQHSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides Bacterial permease ligand according to the BIOPEP-UWM database (ID 3751) Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001) according to the BIOPEP-UWM database of bioactive peptides
Evidence 10 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis
Evidence 11 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber Fibril bundles Trigger=pH: 1.9 or < 2.0 temperature: Room temperature solvent: Water + Tetraphenylporphyrin concentration: 0.1M
Nanofiber Fibril bundles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 1.9 or < 2.0 temperature: Room temperature solvent: Water + Tetraphenylporphyrin concentration: 0.1M
Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and AFM (Atomic Force Microscopy)
25377526
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
pH: 1.9 or < 2.0 temperature: Room temperature solvent: Water + Tetraphenylporphyrin concentration: 0.1M
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
25377526
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly