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Peptide record

TPDB21841

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB21841
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KIPKPLKKFLKKL
Physicochemical Analysis
C79H141N19O14
ARNDCEQGHMSTWYV
K
1581.11
11.21
6
0
5
+6
3.72
-0.608
120.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
6
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 6 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C79H141N19O14
1581.11
11.21
+6
3.72
-0.608
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

active against E. coli (MIC6. 25 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 3.13 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 6.25 uM), S. au
Evidence 2 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Enterobacter aerogenes

Source & Reference

NA

Other

active against E. coli (MIC6. 25 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 3.13 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 6.25 uM), B.cereus
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

5 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 3.13 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 6.25 uM), B.cereus (MIC >100uM), S. lactis (MIC 3.13 uM), E. faecalis (MI
Evidence 4 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

3 uM), E. aerogenes (MIC 3.13 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 6.25 uM), B.cereus (MIC >100uM), S. lactis (MIC 3.13 uM), E. faecalis (MIC 6.25 uM), E. faecium (M
Evidence 5 Activity

Activity

MIC
Antibacterial
>100 µM

Target

B.cereus

Source & Reference

NA

Other

3.13 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 6.25 uM), B.cereus (MIC >100uM), S. lactis (MIC 3.13 uM), E. faecalis (MIC 6.25 uM), E. faecium (MIC3.13 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

S. lactis

Source & Reference

NA

Other

C > 100 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 6.25 uM), B.cereus (MIC >100uM), S. lactis (MIC 3.13 uM), E. faecalis (MIC 6.25 uM), E. faecium (MIC3.13 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

e (MIC 6.25 uM), S. aureus (MIC 6.25 uM), B.cereus (MIC >100uM), S. lactis (MIC 3.13 uM), E. faecalis (MIC 6.25 uM), E. faecium (MIC3.13 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

E. faecium

Source & Reference

NA

Other

(MIC 6.25 uM), B.cereus (MIC >100uM), S. lactis (MIC 3.13 uM), E. faecalis (MIC 6.25 uM), E. faecium (MIC3.13 uM).
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane mechanism of temporin-1CEc, an antimicrobial peptide isolated from the skin secretions of Rana chensinensis, and its systemic analogs. | Bioorg Chem | 2022