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Peptide record

TPDB21840

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB21840
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KIPKPLKKFAKKT
Physicochemical Analysis
C74H131N19O15
RNDCEQGHMSWYV
K
1526.97
11.21
6
0
4
+6
4.81
-1.108
67.69
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
6
K
0
M
1
F
2
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 6 M: 0 F: 1 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C74H131N19O15
1526.97
11.21
+6
4.81
-1.108
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

S. lactis

Source & Reference

NA

Other

uM), K.pneumoniae (MIC > 100 uM), Gram+ S.aureus (MIC > 100 uM), B.cereus (MIC > 100 uM), S. lactis (MIC 50 uM), E. faecalis (MIC 50 uM), E.faecium (MIC >100 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

> 100 uM), Gram+ S.aureus (MIC > 100 uM), B.cereus (MIC > 100 uM), S. lactis (MIC 50 uM), E. faecalis (MIC 50 uM), E.faecium (MIC >100 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
>100 µM

Target

E.faecium

Source & Reference

NA

Other

(MIC > 100 uM), B.cereus (MIC > 100 uM), S. lactis (MIC 50 uM), E. faecalis (MIC 50 uM), E.faecium (MIC >100 uM).
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane mechanism of temporin-1CEc, an antimicrobial peptide isolated from the skin secretions of Rana chensinensis, and its systemic analogs. | Bioorg Chem | 2022