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Peptide record

TPDB21839

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB21839
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KILKLLKKFLKKL
Physicochemical Analysis
C81H149N19O14
ARNDCEQGHMPSTWYV
K
1613.19
11.21
6
0
7
+6
1.70
0.223
180.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
5
L
6
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 5 K: 6 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C81H149N19O14
1613.19
11.21
+6
1.70
0.223
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

active against E. coli (MIC 6. 25 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 1.56 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 6.25 uM), S. au
Evidence 2 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Enterobacter aerogenes

Source & Reference

NA

Other

active against E. coli (MIC 6. 25 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 1.56 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 3.13 uM), B. cereu
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

5 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 1.56 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 3.13 uM), B. cereus (MIC 12.5 uM), S. lactis (MIC 1.56 uM), E. faecalis (
Evidence 4 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

3 uM), E. aerogenes (MIC 1.56 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 3.13 uM), B. cereus (MIC 12.5 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 1.56 uM), E. faecium
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

B. cereus

Source & Reference

NA

Other

1.56 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 3.13 uM), B. cereus (MIC 12.5 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 1.56 uM), E. faecium (MIC 1.56 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

S. lactis

Source & Reference

NA

Other

> 100 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 3.13 uM), B. cereus (MIC 12.5 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 1.56 uM), E. faecium (MIC 1.56 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

(MIC 6.25 uM), S. aureus (MIC 3.13 uM), B. cereus (MIC 12.5 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 1.56 uM), E. faecium (MIC 1.56 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

E. faecium

Source & Reference

NA

Other

IC 3.13 uM), B. cereus (MIC 12.5 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 1.56 uM), E. faecium (MIC 1.56 uM).
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane mechanism of temporin-1CEc, an antimicrobial peptide isolated from the skin secretions of Rana chensinensis, and its systemic analogs. | Bioorg Chem | 2022