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Peptide record

TPDB21823

Antibacterial Anticancer Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB21823
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
KIFKKFKTIIKKVWRIFGRF
Physicochemical Analysis
C130H207N33O22
ANDCEQHLMPSY
K
2584.28
12.46
8
0
10
+8
0.17
-0.050
92.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
212.83
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
4
I
0
L
6
K
0
M
4
F
0
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 4 L: 0 K: 6 M: 0 F: 4 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
20
C130H207N33O22
2584.28
12.46
+8
0.17
-0.050
Evidence Records 5 records
Evidence 1 Activity

Activity

HC50
Hemolysis
16
Human erythrocytes: HC50=16 ± 2 µM

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Sci Rep. 2019 Aug 2 9(1):11282.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

EC50
Toxicity
3.3±0.2 µM
Cytotoxic
EC50 | 3.3±0.2 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
16±2 µM
Hemolytic Cytotoxic
50% Hemolysis | 16±2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 4 Activity

Activity

HC50
Toxicity
16
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=16 ± 2 µM | Cytotoxicity: HDMEC: EC50=3.3 ± 0.2 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.
Evidence 5 Hemolysis

Activity

16
HC50
Human erythrocytes: HC50=16 ± 2 µM
Hemolysis

Target

Human erythrocytes

Source & Reference

PD_Hemolysis
Sci Rep. 2019 Aug 2 9(1):11282.
DRAMP4
PD_Hemolysis