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Peptide record

TPDB21822

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB21822
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KIFKKFKDWFKKAFHVLGKV
Physicochemical Analysis
C126H192N30O23
RNCEQMPSTY
K
2495.10
10.92
8
1
10
+6
1.86
-0.280
73.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
220.43
0
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
1
H
1
I
1
L
7
K
0
M
4
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 1 K: 7 M: 0 F: 4 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
20
C126H192N30O23
2495.10
10.92
+6
1.86
-0.280
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
22±1 µM
Cytotoxic
EC50 | 22±1 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

HC50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50>100 µM | Cytotoxicity: HDMEC: EC50=22 ± 1 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.