Back to search

Peptide record

TPDB21821

Antibacterial Anticancer Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB21821
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
KIFKKFKDFLKKIFQYLGKV
Physicochemical Analysis
C127H200N28O25
ARNCEHMPSTW
K
2519.16
10.70
7
1
10
+6
1.62
-0.200
92.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
59.15
2
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
1
Q
1
G
0
H
2
I
2
L
7
K
0
M
4
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 2 K: 7 M: 0 F: 4 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
20
C127H200N28O25
2519.16
10.70
+6
1.62
-0.200
Evidence Records 5 records
Evidence 1 Activity

Activity

HC50
Hemolysis
15
Human erythrocytes: HC50=15 ± 2 µM

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Sci Rep. 2019 Aug 2 9(1):11282.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

EC50
Toxicity
10.1±0.2 µM
Cytotoxic
EC50 | 10.1±0.2 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
15±2 µM
Hemolytic Cytotoxic
50% Hemolysis | 15±2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 4 Activity

Activity

HC50
Toxicity
15
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=15 ± 2 µM | Cytotoxicity: HDMEC: EC50=10.1 ± 0.2 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.
Evidence 5 Hemolysis

Activity

15
HC50
Human erythrocytes: HC50=15 ± 2 µM
Hemolysis

Target

Human erythrocytes

Source & Reference

PD_Hemolysis
Sci Rep. 2019 Aug 2 9(1):11282.
DRAMP4
PD_Hemolysis