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Peptide record

TPDB21818

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

50 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB21818

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

Peptipedia Antifungipept CAFPdb DRAMP dbAMP

Sequence_Type

standard

Has_Modification No

Description A 50-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.

Sequence

KICERASGTWKGICIHSNDCNNQCVKWENAGSGSCHYQFPNYMCFCYFNC

FASTA

>TPDB21818|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=50
KICERASGTWKGICIHSNDCNNQCVKWENAGSGSCHYQFPNYMCFCYFNC

Formula C247H356N70O73S9

Absent Amino Acids L

Common Amino Acids C

Mass 5762.51

PI 7.51

Basic Residues 6

Acidic Residues 3

Hydrophobic Residues 15

Net Charge +1

Boman Index 2.54

Hydrophobicity -0.446

Aliphatic Index 33.20

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 15970

Absorbance 280nm 277.14

Polar Residues 24

number

Amino Acid Distribution

A: 2 R: 1 N: 6 D: 1 C: 8 E: 2 Q: 2 G: 4 H: 2 I: 3 L: 0 K: 3 M: 1 F: 3 P: 1 S: 4 T: 1 W: 2 Y: 3 V: 1

Length

Formula

C247H356N70O73S9

Mass

5762.51

7.51

Net Charge

Boman Index

2.54

Hydrophobicity

-0.446

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism B. sorokiniana

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

separate the two peptides, their antifungal activity was tested together. Active against B. sorokiniana (IC50 0.5 uM), F. oxysporum (IC50 0.35 uM), F. graminearum (IC50 0.52 uM), F. graminearum (IC50 0.52 uM

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 0.35 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

eir antifungal activity was tested together. Active against B. sorokiniana (IC50 0.5 uM), F. oxysporum (IC50 0.35 uM), F. graminearum (IC50 0.52 uM), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM),

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 0.52 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ested together. Active against B. sorokiniana (IC50 0.5 uM), F. oxysporum (IC50 0.35 uM), F. graminearum (IC50 0.52 uM), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM), Ph. betae (IC50 0.52 uM), and P

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 0.52 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

B. sorokiniana (IC50 0.5 uM), F. oxysporum (IC50 0.35 uM), F. graminearum (IC50 0.52 uM), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM), Ph. betae (IC50 0.52 uM), and P. debaryanum (IC50 0.5 uM). Pro

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 1.0 µM

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

. oxysporum (IC50 0.35 uM), F. graminearum (IC50 0.52 uM), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM), Ph. betae (IC50 0.52 uM), and P. debaryanum (IC50 0.5 uM). Provided by Biswajit Mishra.

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 0.52 µM

Target

Target Organism h. betae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

F. graminearum (IC50 0.52 uM), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM), Ph. betae (IC50 0.52 uM), and P. debaryanum (IC50 0.5 uM). Provided by Biswajit Mishra. Updated 7/2021 GW.

Evidence 7 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism P. debaryanum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM), Ph. betae (IC50 0.52 uM), and P. debaryanum (IC50 0.5 uM). Provided by Biswajit Mishra. Updated 7/2021 GW.

Evidence 8 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 0.5 µM

Target

Target Organism B. sorokiniana

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 0.35 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 0.52 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 0.52 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 1.0 µM

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 0.52 µM

Target

Target Organism h. betae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

F. graminearum (IC50 0.52 uM), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM), Ph. betae (IC50 0.52 uM), and P. debaryanum (IC50 0.5 uM). Provided by Biswajit Mishra. Updated 7/2021 GW.

Evidence 14 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 0.5 µM

Target

Target Organism P. debaryanum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM), Ph. betae (IC50 0.52 uM), and P. debaryanum (IC50 0.5 uM). Provided by Biswajit Mishra. Updated 7/2021 GW.

Evidence 15 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 0.5 µM

Target

Target Organism B. sorokiniana

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 0.35 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 0.52 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 0.52 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 1.0 µM

Target

Target Organism B. cinerea

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 0.52 µM

Target

Target Organism h. betae

Source & Reference

Database Source DRAMP

Other

Evidence Text

F. graminearum (IC50 0.52 uM), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM), Ph. betae (IC50 0.52 uM), and P. debaryanum (IC50 0.5 uM). Provided by Biswajit Mishra. Updated 7/2021 GW.

Evidence 21 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 0.5 µM

Target

Target Organism P. debaryanum

Source & Reference

Database Source DRAMP

Other

Evidence Text

), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM), Ph. betae (IC50 0.52 uM), and P. debaryanum (IC50 0.5 uM). Provided by Biswajit Mishra. Updated 7/2021 GW.

Evidence 22 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 0.5 µM

Target

Target Organism B. sorokiniana

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 0.35 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 0.52 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 0.52 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 1.0 µM

Target

Target Organism B. cinerea

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 0.52 µM

Target

Target Organism h. betae

Source & Reference

Database Source DRAMP

Other

Evidence Text

F. graminearum (IC50 0.52 uM), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM), Ph. betae (IC50 0.52 uM), and P. debaryanum (IC50 0.5 uM). Provided by Biswajit Mishra. Updated 7/2021 GW.

Evidence 28 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 0.5 µM

Target

Target Organism P. debaryanum

Source & Reference

Database Source DRAMP

Other

Evidence Text

), F. graminearum (IC50 0.52 uM), B. cinerea (IC50 1.0 uM), Ph. betae (IC50 0.52 uM), and P. debaryanum (IC50 0.5 uM). Provided by Biswajit Mishra. Updated 7/2021 GW.