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Peptide record

TPDB21777

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Antifungal Antihypertensive Toxicity Umami iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB21777
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antibacterial Antifungal Antihypertensive Toxicity Umami iDPPIV
Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides Food sensory peptides
Peptipedia CAFPdb dbAMP AHTPDB AHTpin Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
KG
Physicochemical Analysis
C8H17N3O3
ARNDCEQHILMFPSTWYV
GK
203.24
10.10
1
0
0
+1
1.00
-2.150
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C8H17N3O3
203.24
10.10
+1
1.00
-2.150
203.2382
203.1266
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
3200.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1 MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407
1980
Journal

Other

2
BIOPEP database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)NCC(=O)O InChI=1S/C8H17N3O3/c9-4-2-1-3-6(10)8(14)11-5-7(12)13/h6H,1-5,9-10H2,(H,11,14)(H,12,13)/t6-/m0/s1 InChIKey: HGNRJCINZYHNOU-LURJTMIESA-N Inhibitor of Saccharopine dehydrogenase (EC 1.5.1.8) according to the BRENDA database Inhibitor of Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides Umami peptide according to the BIOPEP database of sensory peptides and amino acids (ID 365) Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 366)
Evidence 2 Activity

Activity

IC50
Antihypertensive
3200.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1 MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)NCC(=O)O InChI=1S/C8H17N3O3/c9-4-2-1-3-6(10)8(14)11-5-7(12)13/h6H,1-5,9-10H2,(H,11,14)(H,12,13)/t6-/m0/s1 InChIKey: HGNRJCINZYHNOU-LURJTMIESA-N Inhibitor of Saccharopine dehydrogenase (EC 1.5.1.8) according to the BRENDA database Inhibitor of Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides Umami peptide according to the BIOPEP database of sensory peptides and amino acids (ID 365) Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 366)
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
>1000 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >1000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
1000 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 1000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
>4000 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >4000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic Net Charge and Counter Ion Type as Antimicrobial Activity Determinant Factors of Short Lipopeptides. | Front Microbiol | 2017
Evidence 7 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73
2015
Journal

Other

2
BIOPEP database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)NCC(=O)O InChI=1S/C8H17N3O3/c9-4-2-1-3-6(10)8(14)11-5-7(12)13/h6H,1-5,9-10H2,(H,11,14)(H,12,13)/t6-/m0/s1 InChIKey: HGNRJCINZYHNOU-LURJTMIESA-N Inhibitor of Saccharopine dehydrogenase (EC 1.5.1.8) according to the BRENDA database Inhibitor of Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1 MEROPS ID: XM02-001) according to the AHTPDB database, the BindingDB database the BIOPEP database of bioactive peptides the ChEMBL database the EROP-Moscow database the PubChem database Umami peptide according to the BIOPEP database of sensory peptides and amino acids (ID 365) Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 366)
Additional Detail Fields 1 fields
2