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Peptide record

TPDB21773

Hilytefluor 488-IP-1 TAMRA-IP-1 IP-1 Antibacterial Antifungal Cell-penetrating Peptides Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB21773
Hilytefluor 488-IP-1 TAMRA-IP-1 IP-1
Antibacterial Antifungal Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia CAFPdb dbAMP CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Antifungal, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
KFLNRFWHWLQLKPGQPMY
Physicochemical Analysis
C122H173N31O24S1
ADCEISTV
L
2489.97
10.72
4
0
9
+3
-2.57
-0.726
61.58
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
12490
501.61
4
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
2
Q
1
G
1
H
0
I
3
L
2
K
1
M
2
F
2
P
0
S
0
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 1 I: 0 L: 3 K: 2 M: 1 F: 2 P: 2 S: 0 T: 0 W: 2 Y: 1 V: 0
Chemical Descriptors
19
C122H173N31O24S1
2489.97
10.72
+3
-2.57
-0.726
Free
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 7 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

S. cerevisiae MATa (BY4741), MAT (BY4742) cells or C. glabrata cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophore (Hilytefluor 488 and TAMARA)
Easily internalized
Endocytosis independent fashion
In vitro
CCSTTTSSTTTCTTSCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

S. cerevisiae MATa (BY4741), MAT (BY4742) cells or C. glabrata cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Fluorophore (TAMRA)
Easily internalized
Endocytosis independent fashion
In vitro
CCSTTTSSTTTCTTSCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

S. cerevisiae MATa (BY4741), MAT (BY4742) cells or C. glabrata cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Fluorophore (Hilyteflour)
Easily internalized
Endocytosis independent fashion
In vitro
CCSTTTSSTTTCTTSCCC
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Moonlighting peptides with emerging function. | PLoS One | 2012
Evidence 5 Activity

Activity

25% Killing
Toxicity
50 µM
Cytotoxic
25% Killing | 50 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Antimicrobial Peptide against Mycobacterium Tuberculosis That Activates Autophagy Is an Effective Treatment for Tuberculosis. | Pharmaceutics | 2020
Evidence 6 Activity

Activity

68% Killing
Toxicity
50 µM
Cytotoxic
68% Killing | 50 | µM | target cell: Mouse Embryonic Fibroblasts (MEF)

Target

Mouse Embryonic Fibroblasts (MEF)

Source & Reference

NA
DBAASP
Antimicrobial Peptide against Mycobacterium Tuberculosis That Activates Autophagy Is an Effective Treatment for Tuberculosis. | Pharmaceutics | 2020
Evidence 7 Activity

Activity

25% Killing
Toxicity
64 µM
Cytotoxic
25% Killing | 64 | µM | target cell: Murine macrophage cells J774A.1

Target

Murine macrophage cells J774A.1

Source & Reference

NA
DBAASP
Antimicrobial Peptide against Mycobacterium Tuberculosis That Activates Autophagy Is an Effective Treatment for Tuberculosis. | Pharmaceutics | 2020
Additional Detail Fields 1 fields
CCSTTTSSTTTCTTSCCC