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Peptide record

TPDB21761

Antibacterial Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB21761
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 9-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KFDLKVTIK
Physicochemical Analysis
C52H90N12O13
ARNCEQGHMPSWY
K
1091.36
10.32
3
1
4
+2
2.41
-0.067
118.89
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
3
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
9
C52H90N12O13
1091.36
10.32
+2
2.41
-0.067
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µM

Target

Klebsiella pneumoniae KPC

Source & Reference

NA

Other

Active against Gram- E. coli EHEC O157:H7 (MIC 32 uM), K. pneumoniae KPC (MIC 64 uM), A. baumanii (MIC 128 uM), but not active against Gram+ S.aureus MDR (MIC > 128 uM), E. f
Evidence 2 Activity

Activity

MIC
Antibacterial
128 µM

Target

A. baumanii

Source & Reference

NA

Other

Active against Gram- E. coli EHEC O157:H7 (MIC 32 uM), K. pneumoniae KPC (MIC 64 uM), A. baumanii (MIC 128 uM), but not active against Gram+ S.aureus MDR (MIC > 128 uM), E. faecalis (MIC > 128 uM) S.a
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Probing human proteins for short encrypted antimicrobial peptides reveals Hs10, a peptide with selective activity for gram-negative bacteria. | Biochim Biophys Acta | 2022
Evidence 4 Activity

Activity

10% Cell death
Toxicity
128 µM
Cytotoxic
10% Cell death | 128 | µM | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Probing human proteins for short encrypted antimicrobial peptides reveals Hs10, a peptide with selective activity for gram-negative bacteria. | Biochim Biophys Acta | 2022