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Peptide record

TPDB21739

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Renin inhibitor ACE inhibitors Antibacterial Antifungal Antihypertensive Bitter Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB21739
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Renin inhibitor
ACE inhibitors Antibacterial Antifungal Antihypertensive Bitter Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides Food sensory peptides
Peptipedia CAFPdb dbAMP AHTPDB AHTpin Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
KF
Physicochemical Analysis
C15H23N3O3
ARNDCEQGHILMPSTWYV
KF
293.37
10.10
1
0
1
+1
-0.14
-0.550
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C15H23N3O3
293.37
10.10
+1
-0.14
-0.550
293.3605
293.1734
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
28.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315.
2006
book

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)O InChI=1S/C15H23N3O3/c16-9-5-4-8-12(17)14(19)18-13(15(20)21)10-11-6-2-1-3-7-11/h1-3,6-7,12-13H,4-5,8-10,16-17H2,(H,18,19)(H,20,21)/t12-,13-/m0/s1 InChIKey: QCZYYEFXOBKCNQ-STQMWFEESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Another value of peptide EC50 = 7.23 Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476 Found in pea protein hydrolysate Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 8248) Inhibitor of calmodulin-dependent phosphodiesterase 1 (CaMPDE) (EC 3.1.4.17) according to the BIOPEP-UWM database of bioactive peptides (ID 8249) Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8809) Inhibitor of Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Bitter peptide according to BIOPEP-UWM database of sensory peptides and amino acids
Evidence 2 Activity

Activity

IC50
Antihypertensive
28.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315.
2006
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)O InChI=1S/C15H23N3O3/c16-9-5-4-8-12(17)14(19)18-13(15(20)21)10-11-6-2-1-3-7-11/h1-3,6-7,12-13H,4-5,8-10,16-17H2,(H,18,19)(H,20,21)/t12-,13-/m0/s1 InChIKey: QCZYYEFXOBKCNQ-STQMWFEESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Another value of peptide EC50 = 7.23 Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476 Found in pea protein hydrolysate Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 8248) Inhibitor of calmodulin-dependent phosphodiesterase 1 (CaMPDE) (EC 3.1.4.17) according to the BIOPEP-UWM database of bioactive peptides (ID 8249) Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8809) Inhibitor of Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Bitter peptide according to BIOPEP-UWM database of sensory peptides and amino acids
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007)
renin inhibitor
ren

Source & Reference

AHTPDB
Li H., Aluko R. E.
Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476, 2010
2010
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)O InChI=1S/C15H23N3O3/c16-9-5-4-8-12(17)14(19)18-13(15(20)21)10-11-6-2-1-3-7-11/h1-3,6-7,12-13H,4-5,8-10,16-17H2,(H,18,19)(H,20,21)/t12-,13-/m0/s1 InChIKey: QCZYYEFXOBKCNQ-STQMWFEESA-N Information concerning Renin is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: A01.007 Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BindingDB database the BIOPEP-UWM database of bioactive peptides (ID 7692) the EROP-Moscow database Inhibitor of calmodulin-dependent phosphodiesterase 1 (CaMPDE) (EC 3.1.4.17) according to the BIOPEP-UWM database of bioactive peptides (ID 8249) Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8809) Inhibitor of Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The pharmacophore of short cationic antibacterial peptides. | J Med Chem | 2003
Evidence 5 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)O InChI=1S/C15H23N3O3/c16-9-5-4-8-12(17)14(19)18-13(15(20)21)10-11-6-2-1-3-7-11/h1-3,6-7,12-13H,4-5,8-10,16-17H2,(H,18,19)(H,20,21)/t12-,13-/m0/s1 InChIKey: QCZYYEFXOBKCNQ-STQMWFEESA-N Peptide found in pea protein hydrolysates: Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476 Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BindingDB database the BIOPEP-UWM database of bioactive peptides (ID 7692) the ChEMBL database EROP-Moscow database Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 8248) Inhibitor of calmodulin-dependent phosphodiesterase 1 (CaMPDE) (EC 3.1.4.17) according to the BIOPEP-UWM database of bioactive peptides (ID 8249) Inhibitor of Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids
Additional Detail Fields 1 fields
2