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Peptide record

TPDB21698

Antibacterial Antifungal Antiparasitic Antiviral Toxicity modified_plain modified
16 amino acids
Basic Information
3D PDB MODEL
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TPDB21698
Antibacterial Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP dbAMP 3.0 DRAVP 2.0
modified_plain
Yes
A 16-aa modified multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Modified, details unspecified
Sequence
KALXKTMLKKLGTMAL
Physicochemical Analysis
C74H139N19O18S2
RNDCEQHIFPSWYV
LK
1647.15
11.00
4
0
8
+4
1.21
0.325
110.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
4
L
4
K
2
M
0
F
0
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 4 K: 4 M: 2 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C74H139N19O18S2
1647.15
11.00
+4
1.21
0.325
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
50% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
50 µM
Cytotoxic
50% Cytotoxicity | 50 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µM
Cytotoxic
50% Cytotoxicity | >100 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 4 Activity

Activity

HC50
Toxicity
80 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.20718719]human red cells:HC50=80 µM. | Cytotoxicity: [Ref.20718719]Vero cells:CC50=50 µM 293TT(embryonic human culture cells):CC50>100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
APMIS. 2010 Sep 1 118(9):674-80.