TPDB

3D PDB MODEL

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TPDB ID TPDB21691

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.

Sequence

KAANRIKYFQ

FASTA

>TPDB21691|Antibacterial;Antifungal;Toxicity|length=10
KAANRIKYFQ

Formula C57H91N17O14

Absent Amino Acids DCEGHLMPSTWV

Common Amino Acids AK

Mass 1238.46

PI 10.72

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +3

Boman Index 1.07

Hydrophobicity -0.970

Aliphatic Index 59.00

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 120.31

Polar Residues 3

number

2

A

1

R

1

N

0

D

0

C

0

E

1

Q

0

G

0

H

1

I

0

L

2

K

0

M

1

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

10

Formula

C57H91N17O14

Mass

1238.46

PI

10.72

Net Charge

+3

Boman Index

1.07

Hydrophobicity

-0.970

Evidence 1 Activity

Activity

Activity Endpoint 4% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

4% Hemolysis | 500 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Synthetic antimicrobial peptides: From choice of the best sequences to action mechanisms. | Biochimie | 2020

Evidence 2 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Neutralizing Effect of Synthetic Peptides toward SARS-CoV-2. | ACS Omega | 2022

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Neutralizing Effect of Synthetic Peptides toward SARS-CoV-2. | ACS Omega | 2022

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Mouse fibroblasts L929

Target

Target Cell Mouse fibroblasts L929

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Neutralizing Effect of Synthetic Peptides toward SARS-CoV-2. | ACS Omega | 2022

Evidence 5 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Zebrafish embryos

Target

Target Cell Zebrafish embryos

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Neutralizing Effect of Synthetic Peptides toward SARS-CoV-2. | ACS Omega | 2022